Targeting proteasome ubiquitin receptor Rpn13 in multiple myeloma
نویسندگان
چکیده
منابع مشابه
A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer.
The bis-benzylidine piperidone RA190 covalently binds to cysteine 88 of ubiquitin receptor RPN13 in the 19S regulatory particle and inhibits proteasome function, triggering rapid accumulation of polyubiquitinated proteins. Multiple myeloma (MM) lines, even those resistant to bortezomib, were sensitive to RA190 via endoplasmic reticulum stress-related apoptosis. RA190 stabilized targets of human...
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Thank you for submitting your manuscript on proteasome targeting by ubiquitin-like domains to The EMBO Journal. I apologize for the fact that it has taken somewhat longer than usual to obtain reviews and get back to you with a decision in this case. As you will see from the reports copied below, our three referees acknowledge the potential interest and importance of this work, yet also raise a ...
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Degradation rates of most proteins in eukaryotic cells are determined by their rates of ubiquitination. However, possible regulation of the proteasome's capacity to degrade ubiquitinated proteins has received little attention, although proteasome inhibitors are widely used in research and cancer treatment. We show here that mammalian 26S proteasomes have five associated ubiquitin ligases and th...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2016
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2016.97